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East Anglian Urologists

The East Anglian Urologists (EAU) have traditionally met twice a year since 1985.

In the past, summer meetings were arranged in rotation by one of the training units whilst, each December, the meeting was held in Cambridge and was followed by a Christmas dinner. The structure of the meeting then changed, primarily to meet the demands of training and trainee assessments, and it reduced to an annual function, held over a 2-day period each December at Homerton College, Cambridge (pictured right).

Thanks must go to Karl Storz Endoscopy and, in particular, to Richard Greenhalgh who has been instrumental in arranging the regional meetings over many years, as well as co-ordinating all the additional sponsors.

More recently, meetings have been held in centres around London Stansted Airport to make travel more convenient for the North London urologists who attend.

At the Annual Meeting, both days are given over to clinical and administrative issues. One session is reserved for Consultants only (and constitutes the Regional Advisory Committee) with the second day devoted entirely to invited speakers and the trainees' audit presentations for the Patrick Doyle Prize.

Thanks to a generous grant from the late Michael Handley Ashken, past President of BAUS and former Consultant Urologist at Norfolk & Norwich Hospital, we now invite a guest speaker to give a presentation on a clinical topic.

Previous Meetings

2017 Meeting (Thu 19 Jan 2017)

The East of England Urology Meeting took place at Homerton College, Cambridge on Thursday 19 January 2017, under the chairmanship of Mr William Turner (BAUS Regional Council Member). The meeting was accredited for 6 CPD points by BAUS.

Final programme    Abstract booklet

The car park at Homerton College is approached via Harrison Drive, just to the north of the main college entrance on the west side of Hills Road (see map below).

Meeting Feedback

50 delegates attended the meeting of whom 42 supplied feedback. The scale for responses to the content was from 1 (poor) to 5 (extremely good).

Speakers - Oliver Wiseman, Ben Pullar, Malcolm Lucas, Tim Tyndall, Guy Forster & Hilary Reeve. The scores for organisation & content ranged from 4.3 to 4.8 and, for presentation, from 4.3 to 4.6. On these data, it seems that delegates were generally happy with the content of the meeting.

Feedback and survey results

If you have any comments or suggestions about these data, or how to improve
the quality and utility of future meetings, please email the Regional Adviser

 

2016 Meeting (Thu 17 Nov 2016)

The Annual East of England Regional Meeting and Registrars' Prize Presentations took place at Homerton College, Cambridge on Thursday 17 November 2016, under the chairmanship of Mr William Turner (BAUS Regional Council Member).

Further details will follow later ...

The car park at Homerton College is approached via Harrison Drive, just to the north of the main college entrance on the west side of Hills Road (see map below). The car park entry code will be notified when it is known.

 

East of England Study Day (Wed 6 Apr 2016)

The 2016 East of England Study Day was held in the Weston Auditorium at the University of Hertfordshire. The invited Key expert speaker was Professor Mani Menon (pictured right), a world-leading robotic urological surgeon.

Professor Menon is the Director of the Vattikuti Urology Institute, Detroit, USA. He is also Clinical Professor, Case Western Reserve University School of Medicine, Cleveland; Clinical Professor, New York University, School of Medicine and Adjunct Professor, University of Toledo. 

Full programme

 

2015 Meeting (Thu 5 Nov 2015)

The Annual East of England Regional Meeting and Registrars' Prize Presentations took place at Homerton College, Cambridge on Thursday 5 November 2015, under the chairmanship of Mr Damien Hanbury (BAUS Regional Council Member).

Abstract booklet

 

2013 Meeting (Fri 6 Dec 2013)

Two prizes were awarded at the December 2013 Meeting in Homerton College, Cambridge.

Basic Science Papers

The best paper for the basic science section was awarded to Kasra Saeb-Parsy for his talk entitled "The combination of urine Pap cytology with immunocytochemical detection of minichromosome maintenance protein 2 (MCM-2) in patients with visible haematuria identifies most bladder cancers". 

Abstract

Clinical Papers

The best paper for the clinical section was awarded to Jordan Durrant for his talk entitled "Audit of muscle sampling in trans-urethral resection of bladder tumour". 

Abstract

 

2012 Meeting (Fri 7 Dec 2012)

The 2012 winter meeting was held on 6 & 7 December 2012 at Norfolk & Norwich University Hospital, Norwich.

The winner of the 2012 prize competition was Tom Mitchell who receives a book token valued at £350, and the Patrick Doyle Trainees' Prize for his paper entitled "Androgen receptor signalling in castration-resistant prostate cancer" [with T Mitchell, A Ramos-Montoya, M di Antonio, P Murat, S Ohnmacht, S Jurmeister, M Micco, L Fryer, S Balasubramanian, S Neidle, D Neal]. 

Abstract of the winning presentation

Androgen receptor (AR) signalling remains an important regulatory pathway in castrate resistant prostate cancer, and its transcriptional down-regulation could provide a new line of therapy. A number of small-molecule ligands have previously demonstrated the ability to stabilize G-quadruplex structures and affect gene transcription for those genes whose promoters contain a quadruplex-forming sequence. Herein, we report the formation of new G-quadruplex structure present in the AR promoter in a transcriptionally important location. NMR spectroscopy, circular dichroism, UV spectroscopy and UV thermal melting experiments have been performed to confirm that this sequence does form a G-quadruplex. Fluorescence resonance energy transfer (FRET) melting studies have identified a novel compound, MM45, which stabilizes this G-quadruplex at sub-micromolar concentrations. The effects of MM45 have been investigated in prostate cancer cell lines.

It has been shown to be more efficacious in inhibiting cell growth in AR expressing (including hormone insensitive) cell lines, in comparison to AR negative prostate cancer cell lines. A reporter assay intended to isolate the effect of MM45 on the G-quadruplex sequence, showed dose-dependent transcriptional repression only when the G-quadruplex sequence is present. Dose-dependent transcriptional repression of the AR by MM45 has been demonstrated both at a protein and mRNA level. This proof of concept study paves the route towards a potential alternative treatment pathway in castrate resistant prostate cancer.

 

2011 Meeting (Fri 8 Dec 2011)

The Annual Meeting of East Anglian Urologists was held on 7 & 8 December 2011 at Homerton College, Cambridge.

The Patrick Doyle Trainees' Prize was awarded to Utsav Reddy [with J Weston, NA Burgess, ETS Ho, RD Mills & MA Rochester] of Norfolk & Norwich Hospital for the paper entitled: Can we accurately predict the development of complications after partial nephrectomy?

The Consultant adjudicators for the prize were Mr Mark Rochester (Norwich) and Mr Sunil Sharma (Peterborough).

 

2010 Meeting (Fri 9 Dec 2010)

The 2010 winter meeting was held on 8 & 9 December 2010 at Homerton College, Cambridge.

Mr William Finch [with NC Shah & OJ Wiseman] received a book token valued at £350 and the Patrick Doyle Trainees' Prize for his paper entitled: Endoscopic diagnosis of upper tract TCC: correlating indications, investigations & histology

The Consultant adjudicators for the 2010 prize were Mr Rob Mills (Norwich), Mr Frank O'Brien (Cambridge) & Mr Sunil Sharma (Peterborough).

Abstract of the winning presentation

Purpose: To determine the referral pattern and accuracy of ureteroscopy, biopsy and cytology in predicting upper tract transitional cell carcinoma (TCC)

Materials & methods: From November 2004 to date, 85 diagnostic ureteroscopies have been performed with 40 resulting in a diagnosis of TCC. Indications for referral, radiological, ureteroscopic and cytology results were correlated with diagnosis. Ureteroscopic biopsy data was compared with final histology of 12 nephroureterectomy specimens.

Results: 85 diagnostic ureteroscopies were performed of which 10 were deemed complex (ileal conduit, prior distal ureterectomy, horseshoe kidney). Indications for referral resulting in a positive diagnosis of TCC were: filling defect on imaging – 34%, positive voided urine cytology – 67% , atypical voided urine cytology – 14%, haematuria ?cause – 0%. When a filling defect was seen in combination with positive or atypical cytology, the chances of TCC diagnosis were 89% and 83% respectively. Operative retrograde was predictive of TCC in 78% of cases. Ureteroscopy demonstrated TCC in 90% of cases, with distal ureteric and renal pelvis TCC seen most commonly. Ureteric and renal pelvis washings for cytology were positive for TCC in 52% and 65% of cases respectively. 26 ureteroscopic biopsies were performed: 77% TCC, 8% benign and 15% uninterpretable. 12 ureteroscopic biopsies were correlated with final histology. Of these, 2 (17%) were uninterpretable, 1 (8%) was reported as benign, 1 (8%) correctly identified the final histology and 8 (67%) were upstaged, upgraded or both on final histology.

Conclusions: This study highlights the fact that endoscopic investigation for upper tract TCC is not straightforward. Failure to investigate thoroughly may result in unnecessary major surgery for benign disease. Endoscopic investigation is crucial to identify those patients with upper tract TCC, including those not amenable to conservative therapy. Positive ureteric and renal pelvic cytology is helpful in identifying those patients with higher grade disease.

Ureteroscopic biopsies are not accurate in determining grade or stage of the disease but do help identify patients with higher grade disease not amenable to conservative therapy.

Slide presentation